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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 5, 2012, pp. 747-752
Bioline Code: pr12088
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 747-752

 en Effect of Metformin on Potassium-adapted and Nonadapted Diabetic Rats
Owolabi, OJ & Omogbai, EKI

Abstract

Purpose: To assess the effects of potassium adaptation on some biochemical parameters in diabetic rats treated with metformin.
Methods: Diabetes was induced via intraperitoneal administration of streptozotocin in potassiumadapted and non-adapted rats and, then metformin (350 mg/kg) was administered orally. The following parameters were then evaluated 24 h after drug administration: urine volume, plasma glucose, plasma and urine creatinine and creatinine clearance. Lipid profiles and plasma and urine urea were also determined.
Results: The blood glucose of the potassium-adapted diabetic group was not significantly reduced on treatment with metformin, compared to non-adapted diabetic rats which were significantly reduced (p < 0.05) on metformin treatment. The potassium-adapted group treated with metformin had significantly higher creatinine clearance (p < 0.05) than the non adapted group. Urine volumes for both the diabetic and the potassium-adapted diabetic rats were significantly lower (p < 0.05) on treatment with metformin.
Conclusion: The results indicate that potassium adaptation induces resistance to treatment with metformin and increases creatinine clearance in diabetic rats.

Keywords
Metformin, hypoglycemia, potassium, adapted rats, non-adapted rats.

 
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