Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 11, No. 5, 2012, pp. 747-752
Bioline Code: pr12088
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 747-752
© Copyright 2012 - Tropical Journal of Pharmaceutical Research
Effect of Metformin on Potassium-adapted and Nonadapted Diabetic Rats|
Owolabi, OJ & Omogbai, EKI
To assess the effects of potassium adaptation on some biochemical parameters in diabetic
rats treated with metformin.
Diabetes was induced via intraperitoneal administration of streptozotocin in potassiumadapted
and non-adapted rats and, then metformin (350 mg/kg) was administered orally. The following
parameters were then evaluated 24 h after drug administration: urine volume, plasma glucose, plasma
and urine creatinine and creatinine clearance. Lipid profiles and plasma and urine urea were also
The blood glucose of the potassium-adapted diabetic group was not significantly reduced on
treatment with metformin, compared to non-adapted diabetic rats which were significantly reduced (p < 0.05) on metformin treatment. The potassium-adapted group treated with metformin had significantly
higher creatinine clearance (p < 0.05) than the non adapted group. Urine volumes for both the diabetic
and the potassium-adapted diabetic rats were significantly lower (p < 0.05) on treatment with metformin.
The results indicate that potassium adaptation induces resistance to treatment with
metformin and increases creatinine clearance in diabetic rats.
Metformin, hypoglycemia, potassium, adapted rats, non-adapted rats.
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