Purpose: To investigate the effect of ethyl acetate extract of
S. striata
on pro-inflammatory production
by macrophages.
Methods: Mouse peritoneal macrophages were cultured in solvent either alone or with 2 µg/ml
lipopolysaccaride (LPS) with/without different doses of ethyl acetate extract of
S. striata. Production of
pro-inflammatory cytokines including interleukin 1β (IL-1β), tumor necrosis factor - a (TNF-a) and
prostaglandin E2 (PGE2) were examined using ELISA.
Results: Ethyl acetate fraction of
S. striata in doses of 10, 50, 100 and 200 µg/ml significantly (p<0.05)
inhibited pro-inflammatory mediators (IL-1β, TNF-a, and PGE2) production by LPS stimulated peritoneal
macrophages.
Conclusion: The anti-inflammatory effect of the extract on pro-inflammatory cytokines may ameliorate
inflammatory diseases, possibly via an immunomodulatory mechanism.
