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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 6, 2012, pp. 893-897
Bioline Code: pr12105
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 6, 2012, pp. 893-897

 en Inhibition of Pro-inflammatory Cytokines by Ethyl Acetate Extract of Scrophularia striata check for this species in other resources
Azadmehr, Abbas; Maliji, Ghorban; Hajiaghaee, Reza; Shahnazi, Mojtaba & Afaghi, Ahmad

Abstract

Purpose: To investigate the effect of ethyl acetate extract of S. striata check for this species in other resources on pro-inflammatory production by macrophages.
Methods: Mouse peritoneal macrophages were cultured in solvent either alone or with 2 µg/ml lipopolysaccaride (LPS) with/without different doses of ethyl acetate extract of S. striata. Production of pro-inflammatory cytokines including interleukin 1β (IL-1β), tumor necrosis factor - a (TNF-a) and prostaglandin E2 (PGE2) were examined using ELISA.
Results: Ethyl acetate fraction of S. striata in doses of 10, 50, 100 and 200 µg/ml significantly (p<0.05) inhibited pro-inflammatory mediators (IL-1β, TNF-a, and PGE2) production by LPS stimulated peritoneal macrophages.
Conclusion: The anti-inflammatory effect of the extract on pro-inflammatory cytokines may ameliorate inflammatory diseases, possibly via an immunomodulatory mechanism.

Keywords
Pro-inflammatory, Cytokines, Ethyl acetate extract, Scrophularia striata

 
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