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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 6, 2012, pp. 1023-1027
Bioline Code: pr12121
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 6, 2012, pp. 1023-1027

 en Therapeutic Applications of Interleukin 24 (IL24): A Review
Amirzada, Muhammad Imran & Jin, Jian

Abstract

Fisher's group identified melanoma differentiation-associated protein-7 (MDA-7) upon discovery of cell surface receptor MDA-7 renamed Interleukin 24 (IL24).It has three N-glycosylation sites. IL24 signals through receptors. Binding of IL24 to receptors leads to the activation of STAT-3 and STAT-1. IL 24 induces the secretion of high level of Interferon Gamma (IFN-γ) ,IL6 and tumor necrosis factor alpha (TNF-α) and low levels of IL1,IL12 and granulocyte macrophage colony stimulating factor (GM-CSF) from human peripheral blood mononuclear cells(PBMC). IL24 has growth suppressive properties in a wide variety of human cancer cell lines without inducing harmful effects in normal cells. This review is focused on the role of IL 24 on tumor cell biology and its potential therapeutic applications.

Keywords
Melanoma differentiation, Protein, Therapeutics, Interleukin, N-glycosylation, Cancer

 
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