Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 12, No. 1, 2013, pp. 19-25
Bioline Code: pr13004
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 12, No. 1, 2013, pp. 19-25
© Copyright 2013 - Tropical Journal of Pharmaceutical Research
Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen|
Ofokansi, K.C.; Kenechukwu, F.C.; Isah, A.B. & Okigbo, E.L.
glutaraldehyde-cross-linked chitosan-based microparticles and evaluate its suitability for the delivery of
ibuprofen, a BCS class II drug.
Methods: Ibuprofen-loaded chitosan microparticles were prepared by emulsification-cross-linking
technique using glutaraldehyde saturated toluene (GST) as the cross-linking agent. The microparticles
were characterized with respect to morphology, particle size, microparticle yield and entrapment
efficiency. The swelling behaviour of the particles and ibuprofen release were assessed in both
simulated gastric fluid (SGF) without pepsin (pH 1.2) and simulated intestinal fluid (SIF) without
pancreatin (pH 7.4).
Results: Discrete and free-flowing microparticles of size range 100.05 ± 8.82 to 326.70 ± 10.43 μm
were obtained. The microparticles had a high yield (69.2 to 99.2 %) and exhibited greater water sorption
capacity in SIF (122.2 %) than in SGF (60 %). Furthermore, the microparticles cross-linked with 10 ml of
GST entrapped the highest amount of drug (23.32 ± 0.97 %) while those cross-linked with 25 ml GST
had the highest yield of the microparticles (99.19 % ), and highest water sorption in SIF (122.2 %). Up to
93.6 % of the entrapped drug was released in SIF from microparticles cross-linked with 25 ml of GST.
Drug release from microparticles cross-linked with 20 and 30 ml each of GST showed a biphasic
Conclusions: Entrapment of ibuprofen in glutaraldehyde-cross-linked chitosan microparticles can be
exploited to target and control the release of the drug and possibly reduce its gastro-erosive side
Chitosan microparticles, Ibuprofen, Oral delivery, Gastrointestinal, Glutaraldehyde
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