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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 2, 2013, pp. 203-208
Bioline Code: pr13032
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 2, 2013, pp. 203-208

 en Sedative and Anticonvulsant Activities of the Ethanol Root Extract of Flemingia chappar check for this species in other resources Benth
Gahlot, Kavita; Abid, Mohd; Lal, VK & Jha, S

Abstract

Purpose: To investigate the sedative, hypnotic and anticonvulsant activities of the ethanol extract of the roots of the Flemingia chappar check for this species in other resources (ERFC) on the central nervous system (CNS) of mice.
Methods: The ethanol extract of the roots of F. chappar in doses of 200, 400 and 600 mg/kg, p.o., was studied in mice for its sedative effect by evaluating its locomotor activity; its hypnotic effect was assessed by measuring pentobarbital–induced sleeping time, while anticonvulsant effect was determined by evaluating its activity on maximal electroshock–induced and pentylenetetrazole-induced seizures. The latency of tonic convulsions and number of animals protected from tonic convulsions were noted.
Results: ERFC (200 - 600 mg/kg) significantly (p < 0.05) decreased locomotor activity. ERFC also produced dose-dependent prolongation of pentobarbitone sleeping time. In addition, ERFC (400 and 600 mg/kg) significantly (p < 0.05) reduced the duration of seizure induced by maximal electroshock (MES), The same dose also protected from pentylenetetrazol-induced tonic seizures and significantly (p < 0.05) delayed the onset of tonic seizures.
Conclusion: The results indicate that the ethanol root extract of F. chappar has sedative and anticonvulsant activities, thus justifying its use in traditional medicine for epilepsy

Keywords
Flemingia chappar, Anticonvulsant activity, Pentylenetetrazole , Electroshock seizure, CNS depressant.

 
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