To investigate the sedative, hypnotic and anticonvulsant activities of the ethanol extract of the roots of the Flemingia chappar
(ERFC) on the central nervous system (CNS) of mice.
The ethanol extract of the roots of F. chappar
in doses of 200, 400 and 600 mg/kg, p.o.
, was studied in mice for its sedative effect by evaluating its locomotor activity; its hypnotic effect was assessed by measuring pentobarbital–induced sleeping time, while anticonvulsant effect was determined by evaluating its activity on maximal electroshock–induced and pentylenetetrazole-induced seizures. The latency of tonic convulsions and number of animals protected from tonic convulsions were noted.
ERFC (200 - 600 mg/kg) significantly (p < 0.05) decreased locomotor activity. ERFC also produced dose-dependent prolongation of pentobarbitone sleeping time. In addition, ERFC (400 and 600 mg/kg) significantly (p < 0.05) reduced the duration of seizure induced by maximal electroshock (MES), The same dose also protected from pentylenetetrazol-induced tonic seizures and significantly (p < 0.05) delayed the onset of tonic seizures.
The results indicate that the ethanol root extract of F. chappar
has sedative and anticonvulsant activities, thus justifying its use in traditional medicine for epilepsy