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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 2, 2013, pp. 209-213
Bioline Code: pr13033
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 2, 2013, pp. 209-213

 en Achillea millefolium check for this species in other resources Aqueous Extract does not Impair Recognition Memory in Mice
Ayoobi, Fatemeh; Roohbakhsh, Ali; Allahtavakoli, Mohammad; Vazirinejad, Reza; Rajabi, Soodeh & Shamsizadeh, Ali

Abstract

Purpose: To investigate the effect of the aqueous extract of Achillea millefolium check for this species in other resources on recognition memory in mice.
Methods: Male mice (35) were used. The aqueous extract of A. millefolium was prepared using a Soxhlet apparatus and injected intraperitoneally in a dose of 50, 250, 500 or 1000 mg/kg daily for 20 days. The control group was treated with saline 1 ml/mouse/day. Tactile learning was assessed using the novel object recognition test (NORT) in a dark room which entailed measurement of the distance travelled during trial and test phases.
Results: Treatment with different doses of A. millefolium did not affect activity levels (based on the distance travelled during trial and test phases). The total time and frequency of visits to the sample objects in trial and test phases were not statistically significant between control and A. millefolium treated groups (p > 0.05). A comparison of the discrimination ratio between the experimental groups revealed no difference. Administration of A. millefolium extract for 20 days did not decrease body weight or cause death in the treated animals.
Conclusion: The result of this study demonstrates that chronic treatment with different doses of the aqueous extract of A. millefolium did not impair recognition memory in mice.

Keywords
Recognition, Memory, Learning, Tactile, Achillea millefolium

 
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