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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 2, 2013, pp. 215-219
Bioline Code: pr13034
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 2, 2013, pp. 215-219

 en Protective Effect of Cinnamomum tamala check for this species in other resources Extract on Gentamicin-Induced Nephrotic Damage in Rabbits
Ullah, Naveed; Azam Khan, Mir; Khan, Taous & Ahmad, Waqar

Abstract

Purpose: To investigate the reno-protective properties of Cinnamomum tamala check for this species in other resources against gentamicin-induced nephrotoxicity in rabbits.
Methods: Rabbits were randomly divided into four groups (n = 6) including Group-1 (normal saline), Group-2 (gentamicin, 80 mg/kg/day), Group-3 (C. tamala, 200 mg/kg/day) and Group-4 (gentamicin, 80 mg/kg/day and C. tamala, 200 mg/kg/day). Body weight, blood urea nitrogen, serum creatinine, creatinine clearance, serum uric acid, urinary volume and urinary protein excretion were measured followed by histological examination.
Results: Gentamicin-treated animals showed significant renal damage as indicated by rise in blood urea nitrogen (54.18 ± 2.60 mg/dl), serum creatinine (4.02 ± 0.14 mg/dl), serum uric acid (2.34 ± 0.12 mg/dl), urinary proteins (3.86 ± 0.32 mg/dl) and decrease in creatinine clearance (0.76 ± 0.09ml/min), urinary volume (126.00 ± 9.09 ml) and body weight (10.80 ± 1.09 %). However, animals treated with gentamicin and C. tamala significantly protected rabbit kidney from structural and functional changes associated with gentamicin.
Conclusion: Based on the findings, it is apparent that concurrent administration of 200 mg/kg/day of C. tamala leaf extract and gentamicin effectively prevented gentamicin-induced renal damage.

Keywords
Cinnamomum tamala, Renal protection, Gentamicin, Renal damage

 
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