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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 2, 2013, pp. 233-238
Bioline Code: pr13037
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 2, 2013, pp. 233-238

 en Thermodynamic and Spectrophotometric Studies of Electron Donor-Acceptor Complexation Between Loratadine and Chloranilic Acid
Ofokansi, Kenneth C & Uzor, Philip F

Abstract

Purpose: To developing a simple, rapid and reliable analytical method for loratadine based on charge transfer complexation with chloranilic acid.
Methods: The complex between loratadine and the complexing agent, chloranilic acid, was formed by mixing appropriate volumes of their solutions in non-aqueous media. Some features of the formed complex, such as molar ratio of the reaction and effect of time, were determined spectrophotometrically. Thermodynamic parameters were determined as well, the method was utilized in the assay of the drug in both bulk and tablet dosage forms.
Results: The complex showed a wavelength of maximum absorption (λmax) at 527 nm (λmax of loratadine alone was 440 nm). Beer’s law was obeyed in the concentration range of 3.2 - 28.8 mg% (r2 = 0.9997). The stoichiometry of the complex was 2:1 (loratadine: chloranilic acid) and the complex was stable for over 60 min. Thermodynamic results show that as temperature changed from 30 to 70 °C, enthalpy change (∆H) was steady at -0.254 kcal.mol-1 while the free energy (∆G) changed from -3.904 to -4.450 kcal.mol-1. The complex appeared to be more stable at the slightly elevated temperature of 50 °C with a value of 757.14 mol-1. Analysis of the drug in both bulk and dosage forms showed good accuracy and precision with recovery ranging from 99.98 ± 1.00 to 100.94 ± 2.39 %.
Conclusion: Charge transfer complexation method with chloranilic acid was successfully developed for the simple, rapid and accurate determination of loratadine.

Keywords
Chloranilic acid; Electron donor-acceptor; Spectrophotometry; Complexation, Loratadine; Charge transfer

 
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