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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 3, 2013, pp. 393-399
Bioline Code: pr13060
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 3, 2013, pp. 393-399

 en Antihypertensive Activity of Aqueous-Methanol Extract of Berberis Orthobotrys check for this species in other resources Bien Ex Aitch in Rats
Alamgeer; Akhtar, Muhamamd S; Jabeen, Qaiser; Akram, Muhammad; Khan, Hafeez U; Karim, Sabeha; Malik, Muhammad NH; Mushtaq, Muhammad N & Salma, Umme


Purpose: To investigate the hypotensive potential of Berberis Orthobotrys check for this species in other resources Bien Ex Aitch (Family: Berberidaceae) in both normotensive and hypertensive rats.
Methods: Aqueous-methanol (70:30) extract of Berberis orthobotrys at doses of 25, 50, 75 and 100 mg/kg was evaluated for its effect on blood pressure and heart rate using non-invasive blood pressure measuring apparatus. After initial screening, 100 mg/kg dose that produced a maximum effect was selected for the antihypertensive study. Median lethal dose (LD50) and sub-chronic toxicity of the extract were also determined. Various biochemical parameters and organ weight were measured using standard procedures.
Results: The extract produced a significant (p < 0.01) decrease in systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP) and heart rate of normotensive rats at all test doses with maximum effect at 100 mg/kg. Similarly, a significant antihypertensive and negative chronotropic effect was observed in both hypertensive models. LD50 of the extract was 200 mg/kg in mice. The extract also exhibited a reduction (p < 0.05) in serum alanine transaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), triglycerides and low density lipoprotein (LDL) levels while a significant (p < 0.05) increase in high density lipoproteins (HDL) level was observed.
Conclusion: It seems that the aqueous-methanol extract of Berberis orthobotrys possesses active compounds which may be responsible for the antihypertensive and negative chronotropic effects in rats.

Antihypertensive; Blood lipids; Egg feed diet; Berberis orthobotrys

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