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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 3, 2013, pp. 425-431
Bioline Code: pr13064
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 3, 2013, pp. 425-431

 en Antioxidant Activity of Pandanus amaryllifolius check for this species in other resources Leaf and Root Extract and its Application in Topical Emulsion
Jimtaisong, Ampa & Krisdaphong, Panvipa

Abstract

Purpose: To develop Thai pandan ( Pandanus amaryllifolius check for this species in other resources ) as an antioxidant ingredient for topical emulsion.
Methods: Dried leaf and root of P. amaryllifolius ( Pandanceae check for this species in other resources ) were extracted separately by maceration with either ethanol or propylene glycol. Antioxidant capacity was investigated by 2,2-diphenyl-1-picry hydrazyl radical (DPPH) and linoleic acid peroxidation method. The total phenolic content was measured by Folin-Ciocalteau assay. Oil-in-water topical emulsions containing the individual extracts were prepared and tested for stability.
Results: Propylene glycol extract exhibited higher DPPH activity and total phenolic content than the ethanol extract while the DPPH activity of the leaf extract was higher than that of the root. The 50 % inhibition concentration (IC50) value of leaf and root extracts was 0.810 and 2.340 mg/ml, respectively. Although the antioxidant activity of the crude extracts was lower than that of standard vitamin C and butylated hydroxytoluene (BHT), the ethanol/propylene glycol solution extract (ethanol was reduced to 50 % extract volume) showed higher inhibition (90.1 %) of linoleic acid peroxidation than 200 ppm of vitamin C (57.1 %) and BHT (71.1 %). An oil-in-water emulsion containing 3 % of the ethanol and propylene glycol extract showed creamy texture with medium viscosity and demonstrated good stability under accelerated aging test.
Conclusion: The results indicate a potential for the development of P. amaryllifolius leaf extract as an antioxidant ingredient in topically applied formulations.

Keywords
Pandanus amaryllifolius; Extraction; Antioxidant; Emulsion; Stability

 
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