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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 4, 2013, pp. 453-456
Bioline Code: pr13068
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 4, 2013, pp. 453-456

 en Physicochemical Properties of Diosmetin and Lecithin Complex
Brad, Korbanjhon & Chen, Chungang

Abstract

Purpose: To improve the hydrophobicity of diosmetin, the complex of diosmetin and lecithin was prepared and its physicochemical properties were characterized in this study.
Methods: The complex of diosmetin and lecithin was prepared by solvent method. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV/Vis), infrared spectrometry (IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-ray diffractometry (XRD).
Results: Based on UV and IR analysis, there was no significant difference between the physical mixture and the complex while SEM showed that diosmetin in the complex did not present a crystal appearance but rather was dispersed in lecithin. DSC thermograms of the complex mainly showed that the presence of lecithin caused the characteristic endothermal peaks of diosmetin to disappear while x-diffractograms showed that the crystalline peaks of diosmetin was absent in the complex.
Conclusion: The complex is held together by non-covalent-bond, and thus a new compound was not formed. Diosmetin in the complex is molecularly dispersed in the lecithin matrix.

Keywords
Diosmetin; Lecithin; Complex; Physicochemical; Non-covalent bond

 
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