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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 5, 2013, pp. 761-765
Bioline Code: pr13094
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 5, 2013, pp. 761-765

 en Isolation of Antidiabetic Principle from Bougainvillea spectabilis check for this species in other resources Willd (Nyctaginaceae) Stem Bark
Jawla, Sunil; Kumar, Yatendra & Khan, Mohammad Sardar Yar

Abstract

Purpose: To isolate and identify the constituents of Bougainvillea spectabilis check for this species in other resources Willd (Nyctaginaceae) stem bark.
Methods: The methanol extract of Bougainvillea spectabilis stem bark powder was suspended in water and extracted with dichloromethane (CH2Cl2), ethyl acetate (EtOAc), and butanol (BuOH) successively. The ethyl acetate fraction was loaded in a column packed with silica gel and eluted with a gradient of chloroform (CHCl3): methanol (MeOH), and water yielded five fractions (A - E). Chemical constituents were isolated by repeated column chromatography of these fractions.
Results: Column chromatography of fractions B and C afforded four compounds identified as pinitol, β-sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside. For the first time, pinitol, β-sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside were isolated from the stem bark of B. spectabilis Willd.
Conclusion: An antidiabetic principle, pinitol, was successfully isolated from the stem bark of B. spectabilis Willd.

Keywords
Bougainvillea spectabilis; Column chromatography; Pinitol; Quercetin; Quercetin-3-O-α-L-rhamnopyranoside

 
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