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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 5, 2013, pp. 821-825
Bioline Code: pr13103
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 5, 2013, pp. 821-825

 en Investigation of Association between Slime Production by Candida check for this species in other resources Spp and Susceptibility to Fluconazole and Voriconazole
Kaskatepe, Banu & Yildiz, Sulhiye

Abstract

Purpose: To determine the susceptibilities of fluconazole and voriconazole based on slime production by Candida check for this species in other resources spp.
Methods: Candida strains (115) isolated in the period between January 2011 and January 2012 were included in this study. Conventional methods were used for the identification. Candida albicans check for this species in other resources and non-C. albicans isolates were tested for slime production with modified tube adherence test and antifungal resistance with disk diffusion method.
Results: Slime positivity was 31.3 % in all Candida species. Slime positivity in non-C.albicans isolates (44.89 %) was higher than in C. albicans species (21.21 %). All C. albicans isolates were sensitive to fluconazole and voriconazole. The highest resistance to fluconazole (40 %) and voriconazole (5%) was by C. glabrata strains.
Conclusion: Species definition and determination of antifungal susceptibility patterns are advised for the proper management and treatment of patients.

Keywords
Candida; Fluconazole; Voriconazole; Antifungal susceptibility; Slime

 
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