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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 12, No. 5, 2013, pp. 845-850
Bioline Code: pr13106
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 5, 2013, pp. 845-850

 en Association of Biochemical Markers, Hepatitis C Virus and Diabetes Mellitus in Pakistani Males
Bashir, Muhammad Faisal; Haider, Muhammad Saleem; Rashid, Naeem & Riaz, Saba

Abstract

Purpose: To investigate the association between Hepatitis C Virus (HCV) infection and diabetes mellitus (DM), and the effects of these pathological conditions on some biochemical markers in Pakistanis.
Methods: A total number of 4717 chronic HCV patients were enrolled in this study out of which 4250 were positive with the enzyme linked immunosorbant assay (ELISA). Out of this, HCV was detected in 3513 samples by qualitative polymerase chain reaction (PCR). PCR positive samples were divided into: HCV without diabetes ( n = 3136) and HCV with diabetes ( n = 377) groups; 130 patients with diabetes only (negative for HCV ELISA) were also included in the study. Biochemical tests of all three groups were performed to determine liver, diabetic and lipid profiles.
Results: There was increased prevalence of HCV alone and HCV + diabetes patients in the 4th decade of life. Alanine aminotransferase (ALT) titers were higher in HCV patients with diabetes than in HCV patients without diabetes (p ≤ 0.001). Fasting blood glucose was greater in HCV patients with diabetes than in diabetes only patients. Total cholesterol and triglyceride were moderately lower in non-diabetic HCV patients than in diabetes only patients (p ≤ 0.005). However, total cholesterol and triglyceride levels were significantly higher in HCV patients with diabetes than in the other two groups (p ≤ 0.001).
Conclusion: There is positive correlation of HCV with diabetes in the population studied. This association is more pronounced (where there are elevated levels of triglyceride and fasting blood glucose) in HCV patients with diabetes than diabetes patients without HCV infection.

Keywords
Hepatitis C; Diabetes mellitus; Biochemical markers; Lipid profile; Glycosylated haemoglobin

 
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