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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 12, No. 6, 2013, pp. 981-987
Bioline Code: pr13124
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 6, 2013, pp. 981-987

 en Investigation of the Antiasthmatic Properties of Ethanol Extract of Callophyllis japonica check for this species in other resources in Mice
Park, Won Sun; Lee, Kyung Soo; Chun, Jin Ho; Urm, Sang Hwa; Lee, Dae-Sung; Lee, Da-Young; Park, Sae-Gwang; Seo, Su-Kil; Heo, Soo-Jin; Qian, Zhong-ji; Jung, Won-Kyo & Choi, Il-Whan


Purpose: To determine whether an ethanol extract from Callophyllis japonica check for this species in other resources (C. japonica) could attenuate indices of airway inflammation in a murine model of ovalbumin (OVA)-induced asthma.
Methods: The free radical scavenging activity of the C. japonica ethanol extracts (CJE) were investigated using an electron spin resonance (ESR) system. To make develop animal model of asthma, mice were sensitized and challenged with OVA.
Results: CJE exhibited considerable scavenging activity of 71.08 ± 0.73, 79.11 ± 6.04%, 75.95 ± 7.01%, and 48.56 ± 5.96% of DPPH, alkyl, superoxide, and hydroxyl radicals, respectively. The successive intraperitoneal administration of CJE reduced the number of eosinophils in bronchoalveolar lavage (BAL) fluid, development of airway hyperresponsiveness (AHR), an increase in pulmonary Th2 cytokines, and allergen-specific immunoglobulin E (IgE).
Conclusion: Administration of CJE markedly alleviates all indices of airway inflammation. This study provides evidence that CJE plays a critical role in the amelioration of the pathogenetic process of allergic asthma in mice.

Asthma; Phenolic contents; Free radical scavenging; Airway hyper-responsiveness; Cytokines; Immunoglobulin E

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