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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 12, No. 6, 2013, pp. 1029-1034
Bioline Code: pr13131
Full paper language: English
Document type: Editorial
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 12, No. 6, 2013, pp. 1029-1034

 en Making Antibiotic Choices: Formula Derivation and Usage in the Rational Selection of Antibiotics in the Empirical Treatment of Infections
Adorka, Matthias; Lubbe, Martie; Serfontein, Jan; Allen, Kirk & Kabwebwe, Honore Mitonga

Abstract


Purpose: To develop mathematical formulae to aid the selection of antibiotics most appropriate in the empirical treatment of infections.
Methods: Formulae quantifying the characteristics of antibiotics with regard to their cost and activity against associated bacterial isolates of given infections were derived from probability laws. Data from records of culture sensitivity test results were compiled and analysed to ascertain bacterial pathogen associations with infections and their sensitivities to prescribed antibiotics. Applicability of derived formulae was demonstrated in the rational selection of antibiotics most appropriate in the empirical treatment of urinary tract infections (UTIs) in selected hospitals in Lesotho.
Results: Escherichia coli check for this species in other resources , followed by Klebsiella check for this species in other resources spp, Proteus check for this species in other resources spp, non-haemolytic Streptococci check for this species in other resources , Streptococcus pyogenes check for this species in other resources and then, Pseudomonas check for this species in other resources spp were identified as the most common uropathogens at the hospitals studied. Two mathematical formulae were derived and used in quantifying activity and cost characteristics of prescribed antibiotics. Cefotaxime, followed by ciprofloxacin - were considered most appropriate for use in treating UTIs empirically among inpatients of the hospitals.
Conclusion: Quantifying and using procedurally antibacterial activities and cost characteristics of antibiotics provides a suitable means of making antibiotic choices in the empirical treatment of infections.

Keywords
Antibiotics; Derived formulae; Rational selection; Empiric treatment; Urinary tract infection; Lesotho

 
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