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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 13, No. 2, 2014, pp. 211-216
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Bioline Code: pr14030
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 13, No. 2, 2014, pp. 211-216
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Solidified Reverse Micellar Solution (SRMS)-Based Indomethacin Sustained-Release Tablets: Formulation and In vitro Evaluation
Chime, Salome A.; Onyishi, Ikechukwu V.; Onunkwo, Godswill C. & Attama, Anthony A.
Abstract
Purpose: To formulate and evaluate sustained-release indomethacin tablets based on solidified reverse
micellar solution (SRMS).
Methods: SRMS consisting of mixtures of phospholipid (Phospholipon® 90H) and triglyceride (Softisan®
154) were prepared in the ratios of 1:1, 2:1 and 1:2, respectively. SRMS-based tablets containing 75 mg
of indomethacin each were prepared using a validated plastic mould. The physicochemical properties of
the tablet formulations were studied. In vitro release study was carried out in simulated intestinal fluid
(SIF, pH 7.5).
Results: The results showed that the physicochemical properties of the tablet formulations were
significantly affected by the composition/ratio of the lipid matrix used (p < 0.05). Tablet hardness ranged
from 5.00 ± 0.39 to 5.60 ± 0.36 kgf for tablets formulated with SRMS 1:2 and 2:1 (N3 and N2),
respectively. The tablets exhibited friability of < 1 % (p < 0.05). Erosion time in SIF ranged from 124.0 ±
0.5 to 180.0 ± 1.1 min while drug release from the tablets reached a maximum in 8 – 11 h for all the
batches.
Conclusion: Indomethacin tablets based on SRMS exhibited good sustained-release properties and
can be further developed to achieve once daily administration for improved patient adherence to
therapy.
Keywords
Solidified reverse micellar solution; Phospholipid; Triglyceride; Indomethacin; Sustained release
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