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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 2, 2014, pp. 255-259
Bioline Code: pr14037
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 2, 2014, pp. 255-259

 en Susceptibility of Some Bacterial Contaminants Recovered from Commercial Cosmetics in Jordan to Preservatives and Antibiotics
Abu Shaqra, Qasem M.; Al-Momani, Walid & Al-Groom, Rania M.

Abstract

Purpose: To investigate the susceptibility of bacterial contaminants recovered from cosmetics to preservatives and antibiotics.
Methods: Nine bacterial isolates recovered from various brands of commercially available cosmetics marketed in Jordan were tested for their susceptibility pattern against two paraben esters and two formaldehyde donors in addition to nine commonly used antibiotics. The biocidal effect for three preservatives was tested at 0.2 % concentration while the fourth was determined at a strength of 0.3 %. Antibiotic sensitivity test was carried out using standard disc diffusion method.
Results: Isolates of Pseudomonas aeruginosa check for this species in other resources exhibited high resistance pattern to most of the tested preservatives and antibiotics; only one isolate was sensitive to imidazolidinyl urea while others were resistant to the 4 preservatives tested. Each of these isolates exhibited resistance to at least 5 antibiotics. Other organisms, including Escherichia coli check for this species in other resources and Staphylococcus aureus check for this species in other resources , were resistant to the class of preservatives used in the various formulations from which they were recovered and demonstrated resistance to fewer antibiotics. Coagulase-negative staphylococci were the most sensitive to both categories of antimicrobials used. One isolate was sensitive to all preservatives whereas the same isolate was resistant to only co-trimoxazole. Ciprofloxacin and norfloxacin demonstrated the highest in vitro antimicrobial effect against the contaminants investigated.
Conclusion: The bacterial contaminants of cosmetics exhibited variable cross resistance between preservatives and antibiotics. This cross resistance was species- and even strain-specific.

Keywords
Antibiotic; Bacterial contaminant; Cosmetics; Preservative; Resistance

 
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