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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 2, 2014, pp. 261-266
Bioline Code: pr14038
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 2, 2014, pp. 261-266

 en Microbiological Quality of Blister Pack Tablets in Community Pharmacies in Jordan
Abu Shaqra, Qasem M.; Shawaqfah, Maissa T. & Al Momani, Walid

Abstract

Purpose: To investigate the microbiological quality of blister-packed tablets manufactured and marketed in Jordan in order to assess Good Manufacturing Practice by pharmaceutical industries in the country.
Methods: A total of 66 items of 22 registered blister-packed tablet brands were purchased from community pharmacies in Amman. All the items were investigated for total bacterial count and the presence of specified microorganisms using compendial procedures.
Results: Out of 66 items purchased, forty eight (72.7 %) products were free from microbial contamination, while 11 (16.7 %) harbored bacteria in counts < 102 cfu/g. The remaining 7 (10.6 %) items contained counts between 102 and < 103 cfu/g. The most commonly encountered contaminant was Bacillus species but specified objectionable bacteria such as Escherichia coli check for this species in other resources and Staphylococcus aereus check for this species in other resources were not detected. Aspergillus and Penicillium species were isolated in low numbers from few products. Six of the products with the highest stratified bacterial count were manufactured by one company and were also found to be contaminated with Aeromonas species.
Conclusion: This study demonstrates that blister-packed tablets produced by Jordanian pharmaceutical companies are within acceptable microbiological quality but the detection of microbial load in some brands close to the maximum allowable limit suggests the need for better adherence to GMP in the country.

Keywords
Blister pack; Community pharmacy; Good Manufacturing Practice; Microbial contamination; Quality control; Tablets

 
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