Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 3, 2014, pp. 365-368
Bioline Code: pr14053
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 3, 2014, pp. 365-368
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Effect of Resuscitation Fluids on the Expression of hsp90α in Cardiac Muscles of Hemorrhagic Shocked Rats|
Yang, Xiao-Kun; Su, Jie & Xu, Gui-Sen
Purpose: To investigate the protective effects of various resuscitating fluids on severe hemorrhagic shocked (HS) rats by comparing the expression changes of hsp90α in cardiac
muscles and survival of rats.
Methods: Western-blot and immunohistochemistry methods were performed to determine
hsp90α expressions in cardiac muscles of HS rats following treatment with different
resuscitation fluids. In addition, the survival rates of of all the test groups were investigated.
Results: The expression of hsp90α decreased following treatment with resuscitation fluids
based on both Western blot and immunohistochemistry data. Ringer lactate solution (RLS)
was the most effective therapeutic fluid in this regard, and this was buttressed by survival rate
data (90 %).
Conclusion: The expression of hsp90α in rat cardiac muscle is decreased to various
degrees by treatment with different resuscitating fluids, with the effect most pronounced for
ringer lactate solution. Furthermore, hsp90α plays an important role in hemorrhagic rat
cardiac muscle as a regulatory factor.
Resuscitating fluids; Hemorrhagic shock; Heat shock protein 90a; hsp90a
Alternative site location: http://www.tjpr.org