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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 3, 2014, pp. 405-408
Bioline Code: pr14059
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 3, 2014, pp. 405-408

 en Antifungal Activity of Hypericum havvae check for this species in other resources Against Some Medical Candida check for this species in other resources Yeast and Cryptococcus check for this species in other resources Species
Dulger, Gorkem & Dulger, Basaran

Abstract

Purpose: To investigate the antifungal activities of the individual as well as the combined hydroalcohol leaf and root extracts of endemic Hypericum havvae check for this species in other resources A. Guner (Hyperiaceae).
Methods: Each dry powdered plant material (20 g) was soaked in 150 ml of aqueous ethanol (50: 50 %v/v) until complete saturation of the plant material. After the extracts were filtered and evaporated, the antifungal activity of the extracts was tested against medical yeast, Candida (C. albicans ATCC 10231, C. tropicalis check for this species in other resources ATCC 13808, C. guilliermondii check for this species in other resources ATCC 6260) and Cryptococcus ( C. neoformans check for this species in other resources ATCC 90112 and C. laurentii 34142) species by visual broth microdilution method. Minimum inhibitory concentration (MIC) of the extract was derived from the results. Ketoconazole was used as the reference standard.
Results: MIC values ranged from 3.12 to 25.00 mg/ml. The extracts exhibited strong antifungal effect against the yeast cultures but the combination of the plant extracts (leaf + root) possessed stronger antifungal potency against Candida albicans check for this species in other resources and Cryptococcus laurentii check for this species in other resources , with the same MIC value of 1.56 mg/ml.
Conclusion: Our findings support the use of Hypericum havvae in traditional medicine for the treatment of fungal infections, especially Candidiasis.

Keywords
Antifungal activity; Candida; Hypericum havvae; Candidiasis

 
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