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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 3, 2014, pp. 423-428
Bioline Code: pr14062
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 3, 2014, pp. 423-428

 en Multiple-Resistant Commensal Escherichia Coli check for this species in other resources from Nigerian Children: Potential Opportunistic Pathogens
Igbeneghu, Oluwatoyin A. & Lamikanra, Adebayo


Purpose: The antimicrobial susceptibility and virulence traits of 150 strains of Escherichia coli check for this species in other resources characterized as commensals recovered from faecal samples from pre-school age children in Ile-Ife, Nigeria were evaluated in order to determine their potentials for pathogenicity and their contribution to antibiotic resistance in the community.
Methods: The isolates were identified using conventional biochemical methods. The presence or absence of virulence traits was determined using phenotypic and genotypic (polymerase chain reaction) methods. Their susceptibility to antibiotics was determined using the disk diffusion method.
Results: Possession of virulence properties including encapsulation (89.3 %), haemolysin production (24.8 %) and colicinogenicity (11.3 %) was detected among the strains and susceptibility of the strains to multiple antibiotics showed that the strains were highly resistant to cefalothin (100 %), streptomycin (94.0 %), tetracycline (92.0 %), and trimethoprim (89.3 %) while resistance to the quinolones was low (3.3 - 14.0 %).
Conclusion: The possession of virulence properties by antibiotic resistant strains of commensal E. coli may enhance their potential as extraintestinal pathogens.

Escherichia coli; Virulence traits; Haemolysin; Colicin; Capsule; Antibiotic resistance; Drug resistance

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