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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 4, 2014, pp. 489-496
Bioline Code: pr14070
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 4, 2014, pp. 489-496

 en Design and Evaluation of a Novel Gas Formation-Based Multiple-Unit Gastro-Retentive Floating Drug Delivery System for Quetiapine Fumarate
Katakam, Vinay Kumar; Reddy, Sunil; Panakanti, Pavan Kumar & Yamsani, Madhusudan Rao

Abstract

Purpose: To develop a gastro-retentive formulation of quetiapine fumarate in the form of floating minitablets.
Methods: The system consisted of core units prepared by direct compression process, which were coated with three successive layers, namely, an inner seal coat, effervescent layer and an outer polymeric layer of polymethacrylates.
Results: Mini-tablets coated with Eudragit RS 30D (5, 7.5 and 10%) released ≤ 85% of the drug after 12 h, while those coated with Eudragit RL 30D (5, 7.5 and 10%) released ≥ 85% drug within the same period. Drug release kinetic studies showed that drug diffusion fitted best to zero order and Higuchi models, indicating that drug release was anomalous non-Fickian transport. In vivo gastric residence time results indicate that the units remained in the stomach for about 6 h (n = 3). There was no significant change in dissolution profiles before and after storage at 40°C and 75% RH for 6 months.
Conclusion: The developed floating mini-tablets of quetiapine fumarate exhibit prolonged release for ≥12 h, and thus may improve bioavailability and minimize fluctuations in plasma drug concentrations.

Keywords
Mini-tablets; Floating delivery system; Effervescence; Polymeric membrane; Controlled release; Quetiapine fumarate

 
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