Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 4, 2014, pp. 489-496
Bioline Code: pr14070
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 4, 2014, pp. 489-496
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Design and Evaluation of a Novel Gas Formation-Based Multiple-Unit Gastro-Retentive Floating Drug Delivery System for Quetiapine Fumarate|
Katakam, Vinay Kumar; Reddy, Sunil; Panakanti, Pavan Kumar & Yamsani, Madhusudan Rao
Purpose: To develop a gastro-retentive formulation of quetiapine fumarate in the form of floating minitablets.
Methods: The system consisted of core units prepared by direct compression process, which were
coated with three successive layers, namely, an inner seal coat, effervescent layer and an outer
polymeric layer of polymethacrylates.
Results: Mini-tablets coated with Eudragit RS 30D (5, 7.5 and 10%) released ≤ 85% of the drug after
12 h, while those coated with Eudragit RL 30D (5, 7.5 and 10%) released ≥ 85% drug within the same
period. Drug release kinetic studies showed that drug diffusion fitted best to zero order and Higuchi
models, indicating that drug release was anomalous non-Fickian transport. In vivo gastric residence
time results indicate that the units remained in the stomach for about 6 h (n = 3). There was no
significant change in dissolution profiles before and after storage at 40°C and 75% RH for 6 months.
Conclusion: The developed floating mini-tablets of quetiapine fumarate exhibit prolonged release for
≥12 h, and thus may improve bioavailability and minimize fluctuations in plasma drug concentrations.
Mini-tablets; Floating delivery system; Effervescence; Polymeric membrane; Controlled release; Quetiapine fumarate
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