Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 4, 2014, pp. 505-510
Bioline Code: pr14072
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 4, 2014, pp. 505-510
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Development of Sustained-Release Microbeads of Nifedipine and In vitro Characterization|
Bashir, Sajid; Asad, Muhammad; Qamar, Sumbul; ul Hassnain, Fakhar; Karim, Sabiha & Nazir, Imran
Purpose: To formulate and evaluate sustained-release microbeads of nifedipine for prolonged delivery.
Methods: Nifedipine microbeads were prepared using sodium alginate and pectin in different ratios by
ionic-gelation method. The microbeads were evaluated for surface morphology and shape by scanning
electron microscopy (SEM), micromeritic properties, microencapsulation efficiency and in vitro drug
release. The microbeads were also assessed by Fourier Transform Infra-red Spectroscopy (FTIR) and
differential scanning calorimetry (DSC) to determine drug-polymer interaction, if any.
Results: FTIR and DSC results indicate absence of interaction between the drug and polymers used.
Good rheological behavior was demonstrated with an angle of repose < 30º, and Carr’s index and
Hausner’s ratio of < 10% and < 1.12, respectively Microbead size, yield and entrapment efficiency were
in the range of 695 to 733 um, 69 to 75% and 54 to 63%, respectively. SEM revealed that the
microbeads were discrete, largely spherical and free-flowing. Higuchi model was the best fit for the
dissolution data and followed non-Fickian diffusion mechanism.
Conclusion: The microbead formulation would be suitable for sustained release of nifedipine.
Microbead; Nifedipine; Alginate; Ionic gelation; Pectin; Higuchi model; Non-Fickian diffusion
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