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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 5, 2014, pp. 727-730
Bioline Code: pr14103
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 5, 2014, pp. 727-730

 en Molecular Characterization of the Resistance of Mycobacterium tuberculosis check for this species in other resources to Second Line Drugs in Côte d’Ivoire
Ouassa, T; Loukou, YG; Dotia, A & Faye-Kette, H

Abstract

Purpose: To characterize the resistance of Mycobacterium tuberculosis check for this species in other resources to second line drugs using a line probe assay.
Methods: Multi-drug resistant strains of Mycobacterium tuberculosis isolated between December 2008 and December 2009 were tested for resistance to fluoroquinolones and second-line injectable drugs using GenoType® MTBDRsl.
Results: Thirty eight strains gave interpretable results. None of them had a mutation in the gyrA gene. Regarding second-line injectable drugs, 4 strains (11 %) were resistant to aminoglycosides/ capreomycin and all of them harbored A1401G mutation.
Conclusion: No extensive drug resistant strains were observed. A relatively high proportion of strains were resistant to at least one second-line injectable drug. Resistance mechanism seemed similar for all of them.

Keywords
Mycobacterium tuberculosis; Line probe assay; GenoType® MTBDRsl; Aminoglycosides Capreomycin; Mutation

 
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