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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 5, 2014, pp. 753-760
Bioline Code: pr14107
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 5, 2014, pp. 753-760

 en Effect of Aspirin on Fractalkine in Rats with Pulmonary Embolism
Wang, Ling-Cong; Wu, Jian-Nong; Xia, Guo-Lian; Mao, Wei-; Ying, Rong-Biao; Huang, Li-Quan & Jiang, Rong-Lin

Abstract

Purpose: To investigate the effect of aspirin on fractalkine (FKN) in rats with pulmonary embolism (PE).
Methods: Sprague Dawley rats were divided into control group, sham operation group, PE model group and PE + aspirin group. PE was established by injecting self-embolus into the right jugular vein of the rats. Aspirin was administered orally 1 day and 40 min before PE surgery, and daily thereafter. At 4 and 72 h following embolism, the rat lung tissues were obtained for hematoxylin-eosin (HE) staining as well as measurement of mRNA expression of FKN, TNF-α and IL-1β. Additionally, serum FKN, IL-8, TNF-α, and IL-1β were measured by enzyme linked immunosorbent assay (ELISA).
Results: The serum levels of FKN, IL-8, TNF-α and IL-1β were significantly decreased by treatment with aspirin compared with the PE group (p < 0.05). Furthermore, mRNA expressions of lung FKN, TNF- α and IL-1β in PE group were markedly decreased by treatment with aspirin compared with that in PE group. PE-induced lung injury was alleviated by treatment with aspirin based on the results of pathological examination..
Conclusion: Aspirin has protective effects against PE-induced lung injuries, which is probably mediated by the suppression of the expression of IL-8, TNF-α, IL-1β, and FKN.

Keywords
Aspirin; Pulmonary embolism; Lung injury; Fractalkine

 
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