Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 8, 2014, pp. 1215-1223
Bioline Code: pr14168
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 8, 2014, pp. 1215-1223
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Curcumin-Hydroxypropyl-β-Cyclodextrin Inclusion Complex Preparation Methods: Effect of Common Solvent Evaporation, Freeze Drying, and pH Shift on Solubility and Stability of Curcumin|
Jantarat, Chutima; Sirathanarun, Pornpak; Ratanapongsai, Shantika; Watcharakan, Pawut; Sunyapong, Siripa & Wadu, Adil
Purpose: To evaluate the effect of the preparation method on the inclusion complex of curcumin and
hydroxypropyl-β-cyclodextrin (HP- β -CD).
Methods: HP-β-CD was selected to prepare an inclusion complex with curcumin at a molar ratio of 1:1.
The inclusion complexes were prepared using three different methods: common solvent evaporation
(CSE), freeze drying (FD), and pH shift. The inclusion complexes were characterized by differential
scanning calorimetry (DSC) and fourier transform infrared (FTIR) spectroscopy. The content, solubility,
dissolution, and stability of the complexes were evaluated and compared with curcumin and their
Results: Formation of inclusion complexes was confirmed by DSC and FTIR results. CSE and FD
methods gave a high content of curcumin in the inclusion complexes (> 88.39 %), while pH shift gave a
lower content (64.04 %). All three methods significantly (p < 0.05) increased curcumin solubility (>
276.43-fold). However, higher stability complexes were obtained using CSE and FD methods.
Conclusion: Among the three preparation methods (CSE, FD and pH shift) used for the inclusion
complexes, CSE is the most suitable method for preparation of curcumin-HP-β-CD inclusion complex
for increased curcumin solubility and stability.
Curcumin; Cyclodextrin; Inclusion complex; Solubility; Stability; Common solvent evaporation; Freeze drying; pH shift
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