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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 9, 2014, pp. 1385-1391
Bioline Code: pr14191
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 9, 2014, pp. 1385-1391

 en Evaluation of Hydrogels Based on Poloxamer 407 and Polyacrylic Acids for Enhanced Topical Activity of Gentamicin against Susceptible Infections
Nnamani, P.O.; Kenechukwu, F.C.; Anugwolu, C.L. & Attama, A.A.

Abstract

Purpose: To formulate hydrogels based on poloxamer 407 and polyacrylic acids (Carbopols® 971P and 974P), and evaluate its suitability for enhanced topical delivery of gentamicin, a potent but highly toxic aminoglycoside antibiotic.
Methods: Topical hydrogels of gentamicin were produced using poloxamer 407 and polyacrlic acids (Carbopols® 971P and 974P), and evaluated in terms of drug content, pH, physical assessment, viscosity and stability. In vitro antimicrobial drug release was conducted using four microorganisms – Escherichia coli check for this species in other resources , Salmonella typhi check for this species in other resources , Staphylococcus aureus check for this species in other resources and Pseudomonas aeruginosa check for this species in other resources .
Results: Stable gentamicin-loaded hydrogels with good encapsulation efficiency (maximum EE% of 85.76 to 90.66 %) as well as greater zones of inhibition against all organisms (maximum range: 22.34 ± 2.35 to 29.40 ± 3.07 mm) than commercially available gentamicin ointment and pure sample of gentamicin (p < 0.05), were produced. Overall, poloxamer 407 hydrogels of gentamicin gave the most desirable properties in terms of pH, viscosity and rapid concentration and time-dependent antibacterial activity on all tested micro-organisms, superior to polyacrylic acids hydrogels of gentamicin.
Conclusion: This study demonstrates that poloxamer 407 hydrogels of gentamicin may offer a promising approach for topical delivery of gentamicin for the treatment of skin infections caused by gentamicin-susceptible bacteria.

Keywords
Hydrogels; Gentamicin; Polyacrylic acid; Viscosity; Bioactivity; Poloxamer 407

 
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