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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 9, 2014, pp. 1545-1548
Bioline Code: pr14212
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 9, 2014, pp. 1545-1548

 en A Study of the Association of Polymorphism rs5860110 and its Protective Role against Ankylosing Spondylitis in a Chinese Population
Wang, Xiufang & Zhang, Zhaoqing


Purpose: To investigate whether secreted phosphoprotein-1(SPP1) promoter variants are associated with susceptibility to ankylosing spondylitis (AS) in the western China.
Methods: The rs5860110 variant of SPP1 promoter was genotyped using direct sequencing in 120 unrelated AS patients and 106 ethnically matched healthy controls. All the patients were human leukocyte antigen (HLA)-B27 positive. Frequencies of different genotypes and alleles were analyzed among the AS patients and the controls.
Results: In AS patient group, frequency of +254 SPP1 promoter genotype was 0.483 in base TG/TG homozygotes and 0.517 in TG-(deletion)/TG-(deletion) homozygotes, while the values for the control group were 0.311 and 0.689, respectively. However, TG-(deletion)/TG heterozygote was not detected in this study. The rs5860110 single nucleotide polymorphism (SNP) in SPP1 was significantly different when all AS patients were compared to controls (p < 0.01).
Conclusion: The rs5860110 SNP in SPP1 has a protective role against AS in the selected Chinese population.

Polymorphism; Ankylosing spondylitis; Secreted phosphoprotein-1; Sequencing; Genotype; Alleles

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