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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 10, 2014, pp. 1571-1576
Bioline Code: pr14216
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 10, 2014, pp. 1571-1576

 en Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles
Momoh, M.A.; Adedokun, M.O.; Lawal, S.B. & Ubochi, G.O.

Abstract

Purpose: To enhance and control the release of ibuprofen from poly(D,L-lactide-co-glycolide) (PLGA) microparticles.
Methods: Ibuprofen-loaded microparticles containing PLGA were formulated using a emulsification/solvent evaporation method. Various concentrations of ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA microparticles and the formulations labeled A, B, C and D, respectively. The microcapsules were characterized for drug loading, particle size, polydispersity index, zeta potential (ZP) and drug release.
Results: The zeta potential of the microparticles were -53, -68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively. Polydispersity index ranged from 0.745 to 0.900. Encapsulation efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3 and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and 72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve as an alternative carrier for controlled release of ibuprofen.

Keywords
Ibuprofen; Microparticles; Controlled release; Zeta potential; Polydispersity

 
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