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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 10, 2014, pp. 1637-1642
Bioline Code: pr14225
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 10, 2014, pp. 1637-1642

 en Anti-Thrombotic Effect of Carthamus tinctorius check for this species in other resources Linn Extracts in Rats
Wu, Sheng-hao; Zheng, Cui-ping; Chen, Song-yan; Cai, Xiao-ping; Shi, Yue-jian; Liu, Zhen & Li, Zhen-yu

Abstract

Purpose: To explore the effects of Carthamus tinctorius check for this species in other resources L. (CTL) extracts on thrombosis in rats.
Methods: CTL extract was obtained in hot water (60 °C), dried in a hot air oven and then freeze-dried. The rats were divided into 6 groups: normal group, control group, reference group (aspirin 5 mg/kg) as well as groups that received 20, 40 and 80 mg/kg doses of CTL, respectively. For each group, treatment was given orally once daily for 14 days. Common carotid artery FeCl3-induced thrombus and inferior vena cava thrombosis occlusion time, as well as plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandine F1α(6-keto-PGF1α) were measured in rats.
Results: Compared with the control group, all doses of CTL extracts significantly and dose-dependently prolonged thrombosis occlusion time, reduced the weight of thrombus and increased inhibition rate (p < 0.01). Plasma TXB2 concentration of all CTL extracts groups decreased dose-dependently (p < 0.05) while that of 6-keto-PGF1α was increased (p < 0.05). There was association between 6-keto- PGF1α/TXB2 and arterial or venous thrombus weight for all treatments, and also with occlusion time for CTL treatment but not for aspirin.
Conclusion: CTL has a significant effect on thrombosis in rats. However, further studies are required to determine its clinical potentials.

Keywords
Carthamus tinctorius L.; Thrombosis; Thromboxane B2; 6-Keto-prostaglandin F1α; Aspirin; Occlusion time

 
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