search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 10, 2014, pp. 1653-1658
Bioline Code: pr14227
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 10, 2014, pp. 1653-1658

 en Anti-Hyperlipidemic Effect of Flavone-Rich Belamcanda chinensis check for this species in other resources (L.) DC. (Iridaceae) Leaf Extract in ICR Mice Fed High-Fat Diet
Zhao, Hai-Wei; Lv, Fang; Meng, Wei-Wei; Dang, Hao; Sun, Zhi-Long; Chen, Yan; Dai, Rong-Ji; Deng, Yu-Lin & Wu, Chong-Ming

Abstract

Purpose: To assess the anti-hyperlidemic effect of flavone-rich B. chinensis check for this species in other resources leaf extract (HTP) in ICR mice fed a high-fat diet.
Methods: HTP (100, 200 and 400 mg/kg) were orally administered to ICR mice fed high-fat diet for 7 weeks. Blood glucose, as well as serum and hepatic levels of lipids were determined at the end of the experiment. Phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and protein level of peroxisome proliferator-activated receptor α (PPARα) were analyzed by Western blot and enzyme-linked immunosorbent assay (ELISA) kit, respectively.
Results: Treatment with HTP significantly decreased peri-epididymal fat weight (p < 0.01 and p < 0.05 for 200 and 100 mg/kg, respectively), lowered serum and hepatic lipid, and decreased glucose area under curve (AUC) in oral glucose tolerance test (p < 0.01 for 200 mg/kg). Western blot and ELISA analysis showed that administration of HTP (200 mg/kg) significantly increased AMPK (p < 0.05) phosphorylation and PPARα expression in liver (p < 0.05).
Conclusion: HTP can alleviate hyperlipidemia, at least in part, by up-regulation of AMPK and PPARα.

Keywords
Belamcanda chinensis; Flavone; Hyperlipidemia; Adenosine 5'-monophosphate-activated protein kinase; Peroxisome proliferator activated receptor-alpha; Glucose tolerance

 
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 10-Dec-2021.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil