Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 11, 2014, pp. 1791-1796
Bioline Code: pr14246
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1791-1796
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Physiochemical Properties of the Complex of Myricetin and Hydroxypropyl-β-Cyclodextrin|
Nan, Haijuan; Ma, Hanjun; Zhang, Ruiting & Zhan, Rui
Purpose: To improve the hydrophilic property of myricetin by complexing it with hydroxypropyl-β-
Methods: The complexes of myricetin and HP-β-CD were prepared in both water and ethanol. The
physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV),
Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential
scanning calorimetry (DSC) and x-ray diffractometry (XRD).
Results: The content of myricetin in the complex prepared in ethanol (3.71 %) was higher than that
prepared in water (1.43 %). Characterization studies indicate that myricetin in the complex was
molecularly dispersed in HP-β-CD matrix.
Conclusion: Ethanol is the better solvent to prepare the complex of myricetin and hydroxypropyl-β-
cyclodextrin. Myricetin and HP-β-CD in the complex are combined by non-covalent bond, and thus did
not form a new compound.
Myricetin; Hydroxypropyl-β-cyclodextrin; Complexation; Physicochemical properties
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