To determine the antioxidant activity of Crucus sativus
extract and its effect on human skin
using a non-invasive probe mexameter.
The antioxidant activity of C. sativus
extract was determined using DPPH method. Water in
oil (w/o) topical cream of C. sativus
extract (3 %) was formulated and compared with the base (cream
without extract). Both creams (formulation and base) were applied to the cheeks of 10 healthy human
volunteers for a period of 8 weeks. Melanin and erythema values of skin were measured with a
The antioxidant activity of the extract was 81 %. Change in the levels of skin melanin and
erythema was -24.04 ± 3.23 and -13.57 ± 2.28, respectively, indicating that unlike the base, the
formulation containing Crocus sativus
extract produced significant (p ≤ 0.05) depigmentation and anti
erythemic effect on human skin.
Application of the formulation containing 3 % C. sativus
extract to human skin may be
useful in the management of melanoma. However, further studies are still required to ascertain this.