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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 11, 2014, pp. 1833-1836
Bioline Code: pr14252
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1833-1836

 en Evaluation of α-Glucosidase Inhibitory Activity of Dichloromethane and Methanol Extracts of Croton bonplandianum Baill
Qaisar, Muhammad Naeem; Chaudhary, Bashir Ahmad; Sajid, Muhammad Uzair & Hussain, Nawaz

Abstract

Purpose: To evaluate the α-glucosidase inhibitory activity of Croton bonplandianum. Baill as a probable remedy for the management of diabetes.
Methods: Dichloromethane and methanol extracts were prepared and screened for their α-glucosidae inhibitory activity using standard in vitro α-glucosidae inhibition assay. Acarbose was used as positive control.
Results: α-Glucosidae inhibition activity of dichloromethane extract was 97.89 % with 50 % inhibitory concentration (IC50) of 14.93 mg/ml, while the methanol extract was not active. Acarbose (reference) exhibited 92.23 % inhibition with IC50 of 38.25 mg/ml.
Conclusion: The plant contains bioactive compounds with enzyme-inhibiting activity, and thus lends some support for the traditional use of this herb in the management of diabetes. Dichloromethan extract has higher α-glucosidase inhibition activity than the methanol extract. However, further investigation of the plant, including identification of its active components are required.

Keywords
α-Glucosidase; Inhibition; Diabetes; Acarbose; Croton bonplandianum

 
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