Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 11, 2014, pp. 1833-1836
Bioline Code: pr14252
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1833-1836
© 2014 - Tropical Journal of Pharmaceutical Research
Evaluation of α-Glucosidase Inhibitory Activity of Dichloromethane and Methanol Extracts of Croton bonplandianum Baill|
Qaisar, Muhammad Naeem; Chaudhary, Bashir Ahmad; Sajid, Muhammad Uzair & Hussain, Nawaz
Purpose: To evaluate the α-glucosidase inhibitory activity of Croton bonplandianum. Baill as a probable
remedy for the management of diabetes.
Methods: Dichloromethane and methanol extracts were prepared and screened for their α-glucosidae
inhibitory activity using standard in vitro α-glucosidae inhibition assay. Acarbose was used as positive
Results: α-Glucosidae inhibition activity of dichloromethane extract was 97.89 % with 50 % inhibitory
concentration (IC50) of 14.93 mg/ml, while the methanol extract was not active. Acarbose (reference)
exhibited 92.23 % inhibition with IC50 of 38.25 mg/ml.
Conclusion: The plant contains bioactive compounds with enzyme-inhibiting activity, and thus lends
some support for the traditional use of this herb in the management of diabetes. Dichloromethan extract
has higher α-glucosidase inhibition activity than the methanol extract. However, further investigation of
the plant, including identification of its active components are required.
α-Glucosidase; Inhibition; Diabetes; Acarbose; Croton bonplandianum
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