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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 11, 2014, pp. 1837-1843
Bioline Code: pr14253
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1837-1843

 en Extract of Zanthoxylum bungeanum check for this species in other resources Maxim Seed Oil Reduces Hyperlipidemia in Hamsters Fed High-Fat Diet via Activation of Peroxisome Proliferator-Activated Receptor γ
Chen, Gang; Gao, Xue; Zhen, Kong-Shu; Yin, Zhong-Yi & Zheng, Xu-Xu

Abstract

Purpose: To investigate the anti-hyperlipidaemic effect of extract of Zanthoxylum bungeanum check for this species in other resources Maxim. seed oil (EZSO) on high-fat diet (HFD)-induced hyperlipidemic hamsters.
Methods: Following feeding with HFD for 30 days, hyperlipidemic hamsters were intragastrically treated with EZSO for 60 days. Serum levels of triglyceride (TG), total cholesterol (TC), low-density-lipoproteincholesterol (LDL-C), nitric oxide (NO) and malondialdehyde (MDA) were analyzed. Protein expression and location of peroxisome proliferator-activated receptor γ (PPARγ) in liver were determined by Western blot and immunohistochemical assays, respectively.
Results: EZSO at 5 and 10 g/kg significantly reduced levels of TG by 26 and 23 % (p < 0.05), TC by 19 % (p < 0.01) and 13 % (p < 0.01), LDL-C by 18 % (p < 0.05) and 21 % (p < 0.01), NO by 15 % (p < 0.01) and 31 % (p < 0.01), and MDA by 16 % (p < 0.05) and 30 % (p < 0.01), respectively, in serum of hyperlipidemic hamsters. However, EZSO did not show significant effect on HDL-C level in serum. Furthermore, EZSO at 5 and 10 g/kg markedly promoted protein expression of PPARγ by 71 % (p < 0.05) and 102 % (p < 0.01) in liver tissue of hyperlipidemic hamsters. EZSO also notably increased the content of PPARγ protein in the nucleus of liver cells of hyperlipidemic hamsters.
Conclusion: These findings suggest that EZSO can reduce hyperlipidemia and improve oxidative stress in hyperlipidemic hamsters through activation of PPARγ, and that EZSO is a promising novel hypolipidemic health product.

Keywords
Zanthoxylum bungeanum; Peroxisome proliferator activated receptor γ; Hyperlipidemia; Hamster; High-fat diet

 
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