Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 11, 2014, pp. 1899-1902
Bioline Code: pr14261
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1899-1902
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Accumulation of 99mTC-Methylene Diphosphonate Radiotracer in Rat's Forelimb|
Purpose: To evaluate the efficacy and radioactivity counts of technetium-99m methylene
diphosphonate (99mTc-MDP) radiotracer by scintigraphy.
Method: In this study, 7 healthy Wistar rats were anesthetized. Technetium was milked from
molybdenum-technetium generator and added to methylene diphosphonate (MDP) kit. Scintigraphic
scans were carried out in several areas of the rat’s forelimbs by gamma camera 2 h after the injection of
99mTc-MDP via the tail vein. Accumulations of the radioisotope in the study areas were calculated using
region of interest (ROI) technique.
Results: Mean count of radioisotope in the right and left sides of the shoulder area was 4179.29 and
4074.24, respectively; in the right and left sides of the elbow joint areas, the count was 1662.14,
1645.28, respectively. The count in the right and left sides of the carpal joint and finger areas was
1908.42 and 2028.28, respectively.
Conclusion: This study shows that 99mTc-MDP radiotracer can be used for survey radioactivity
examination in different bones of the forelimb. Comparison of radioisotope counts in these areas can be
used for the diagnosis of disease.
Bone; Rat; Scintigraphy; Technetium; Methylene diphosphonate
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