Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 11, 2014, pp. 1903-1909
Bioline Code: pr14262
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1903-1909
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Antidiabetic and Hypolipidemic Effects of Methanol Leaf Extract of Napoleona vogelii (Lecythidaceae) Hook & Planch on Alloxan–Induced Diabetes Mellitus in Rats|
Owolabi, Omonkhelin Josephine; Inninh, Silvanus O.; Anaka, Ogochukwu Ngozi & Iyamu, Osaretin Abiemwense
Purpose: To evaluate the antihyperglycaemic and hypolipidemic effects of Napoleona vogelii Hook. &
Planch (Lecythidaceae) methanol leaves extract in alloxan-induced diabetes in rats.
Methods: The leaves were extracted via cold maceration using 70 % methanol. Diabetes was then
induced using alloxan (150 mg/kg I.P). Alloxan-induced diabetic rats were divided into 5 groups of 5
each and were treated with 100, 200 and 400 mg/kg of the methanol extract. The 4th and 5th diabetic
groups were given glibenclamide (5 mg/kg) and distilled water respectively. The 6th group, normal rats
were given distilled water. Treatment was continued daily and orally for 14 days. Blood glucose levels
were monitored at 0, 2, 4, 8 and 24 h, and 14th days. The lipid profile was determined on the 14th day of
administration. Oral acute toxicity and phytochemical screening were also carried out on the extract.
Results: The extract significantly (p < 0.05) reduce fasting blood glucose level at 100, 200 and 400
mg/kg notably from the 4th hour to the 14th day. The effect of the extract compared well with that of
glibenclamide which also produced significant reduction (p < 0.05) in blood glucose level in the diabetic
rats from the 4th hour onwards. The extract significantly increased and lowered (p < 0.05) High density
lipoprotein (HDL)-cholesterol and Low density lipoprotein (LDL)-cholesterol + triglycerides), respectively,
at 100 and 200 mg/kg doses. Total cholesterol was also significantly reduced (p < 0.05) at 200 and 400
mg/kg doses. Acute toxicity data revealed death at 4 g/kg dose. While phytochemical screening
revealed the presence of flavonoids, saponins, glycosides, tannins and anthraquinones.
Conclusion: These data suggest that Napoleona vogelii leaves have potential hypoglycaemic effect
and could be a useful source of an anti-diabetic agent.
Napoleona vogelii; Lipid profile; Diabetes; Glibenclamide; Hypoglycemic effect
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