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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 11, 2014, pp. 1925-1931
Bioline Code: pr14265
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 11, 2014, pp. 1925-1931

 en Pharmacological Investigation of Selected Medicinal Plants of Bangladesh
Zulfiker, Abu Hasanat Md.; Hoque, Md. Amdadul; Akter, Tanzena; Afroz, Aysha & Momin, Mohammad Abdul Motalib

Abstract

Purpose: To pharmacologically investigate the methanol and petroleum ether extracts of the plant leaves of Manilkara zapota check for this species in other resources (MZME and MZPE, respectively), Abroma augusta check for this species in other resources (AAME and AAPE, respectively) and Vitex negundo check for this species in other resources (VNME and VNPE, respectively).
Methods: Analgesic and anti-diarrheal activities were assessed by acetic acid-induced writhing and castor oil-induced diarrhea in mice, respectively, while CNS depressant activity was evaluated using hole-cross and open-field method by observing the decrease in exploratory behavior and spontaneous motor activity in mice, respectively.
Results: All the extracts exhibited good analgesic activity at a dose of 200 mg/kg with the following rank order of activity: MZME > MZPE > VNME > VNPE > AAME > AAPE. Analgesic activity was insignificant at 100 mg/kg dose except for VNPE (67.81 % inhibition). The extracts produced significant reduction in diarrheal episodes in mice at a dose of 400 mg/kg MZPE (highest protection: 80.3 %, p < 0.05) and VNME (lowest protection: 38.6 %, p < 0.001). The extracts demonstrated CNS depressant activity in a dose-dependent manner (p < 0.05 compared to the standard except for AAME and AAPE which showed insignificant activity).
Conclusion: The results indicate that the traditional use of the investigated plants appears to be justified; however, further studies are required to unravel the underlying mechanisms of action.

Keywords
Manilkara zapota; Abroma augusta; Vitex negundo; Analgesic; Central nervous system depressant; Anti-diarrhoeal

 
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