Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 12, 2014, pp. 1955-1961
Bioline Code: pr14269
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 12, 2014, pp. 1955-1961
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Characterization of Carbamazepine-Loaded Solid Lipid Nanoparticles Prepared by Rapid Expansion of Supercritical Solution|
Akbari, Zahra; Amanlou, Massoud; Karimi-Sabet, Javad; Golestani, Abolfazl & Niasar, Mojtaba Shariaty
Purpose: To prepare carbamazepine-loaded solid lipid nanoparticles (CBZ-SLN) for prolonged release
of CBZ in oral drug delivery.
Methods: CBZ-loaded SLNs were prepared by rapid expansion of supercritical solution (RESS). SLNs
were formulated using stearic acid as the lipid component. Initially, lipid and drug were separately
micronized by RESS process separately. This was followed by co-precipitation of the components with
the two solutes using RESS to produce drug-loaded SLNs. The formulations were characterized by
infrared spectroscopy (IR), scanning electron microscopy (SEM) and ultraviolet spectrophotometry (UV).
Results: Application of RESS to pure stearic acid yielded spherical particles in the range 40 to 200 nm
which was about 600 times smaller than the unprocessed powder based on SEM observation. Similarly,
RESS processing of carbamazepine produced nanoparticles with rod shape. FT-IR analysis showed
that no chemical structure change occurred during RESS processing of both components. Coprecipitation
of drug and lipid using RESS produced SLNs with drug loading capacity of 2.2 %. RESS
yielded ultrafine spherical particles (100 nm) of CBZ-SLNs.
Conclusion: The successful preparation and characterization of carbamazepine-loaded solid lipid
nanoparticles by RESS as well as their characterization has been achieved in this study.
Rapid expansion of supercritical fluid; Stearic acid; Solid lipid nanoparticles; Carbamazepine; Co-precipitation
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