Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 12, 2014, pp. 1963-1970
Bioline Code: pr14270
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 12, 2014, pp. 1963-1970
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Albendazole Microparticles Prepared by Spray Drying Technique: Improvement of Drug Dissolution|
Ibrahim, Mohamed Abbas; Shazly, Gamal A. & El-Badry, Mahmoud
Purpose: To enhance the dissolution of albendazole (ABZ) using spray-drying technique.
Method: ABZ binary mixtures with Kollicoat IR® (KL) and polyvinyl pyrrolidone (PVP) in various drug to
polymer ratios (1: 1, 1: 2 and 1; 4) were prepared by spray-drying. The spray-dried particles were
characterized for particle shape, and dissolution rate as well as by differential scanning
calorimetry(DSC) and Fourier transform infrared (FTIR).
Results: Scanning electron micrographs showed a homogeneous distribution of ABZ in the polymer
matrix for ABZ-PVP spray-dried system in ratios of 1: 2 and 1: 4, while it was observed only upon using
a ratio of ABZ: KL 1: 4 in case of ABZ-KL systems. FT-IR spectra of both physical mixtures and spraydried
mixtures did not show any change for all ABZ-polymer systems, thus indicating the compatibility of
the carriers with ABZ. ABZ exhibited a noticeable enhanced dissolution rate from its spray-dried
coacervate with PVP and this was independent of the drug/polymer ratio. Drug release was 78, 81 and
81 % from the spray-dried ABZ-PVP systems of drug: polymer ratio of 1:1, 1:2 and 1: 4, respectively,
within 5 min. Drug showed complete dissolution within 15 min. On the other hand, enhancement of
dissolution rate varied with ABZ: Kl ratio.
Conclusion: Enhancement of ABZ dissolution for both types of spray-dried particles is due to the
reduction in drug particle sizes, wetting of the dissolution medium by the hydrophilic carriers and the
amorphosization of the drug crystals by the carriers.
Albendazole; Spray-drying; Kollicoat; Polyvinyl pyrrolidone; Dissolution; Amorphous
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