search
for
 About Bioline  All Journals  Testimonials  Membership  News


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 12, 2014, pp. 1987-1992
Bioline Code: pr14273
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 12, 2014, pp. 1987-1992

 en Evaluation and Selection of Gel Base for the Formulation of Dexpanthenol Products
Sipos, Emese; Szász, Noémi; Vancea, Szende & Ciurba, Adriana

Abstract


Purpose: To formulate dexpanthenol gels with enhanced in vivo absorption properties via skin.
Methods: Carboxyvinyl derivatives (Carbopol 980 and Ultrez 10) and poloxamer (Lutrol F 127) were used as the hydrogel base in the formulations. Changes in rheological properties (apparent viscosity and penetration values) during the storage period were examined by Rheotest RN rotational viscometer and PNR12 penetrometer. in vitro release study using Franz diffusion cell was employed to compare the release characteristics of the formulated hydrogels with those of a reference cream.
Results: The flow curves of the gels with Carbopol 980 and Ultrez 10 showed pseudoplastic flow. Lutrol F 127 gels presented thixotropic behaviour. The consistency of the studied gels was in the following rank order: Lutrol F 127 > Ultrez 10 > Carbopol 980. in vitro results showed that dexpanthenol was released in lower amounts from the reference cream than from the three test gels. No significant differences were observed in the amount of active substance released from the gels due probably to the fact that Carbopol 980 and Ultrez 10 are both carboxyvinyl polymers. The highest amount of dexpanthenol was released from Lutrol F 127 gel.
Conclusion: The hydrogel made with Lutrol F 127 gel base possesses the best properties of all the gels and is recommended for the formulation of a suitable dexpanthenol gel.

Keywords
Hydrogel; Dexpanthenol; Carboxyvinyl polymers; Gels; Carbopol; Poloxamer; Rheology; Drug release; Penetrometer

 
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil