Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 13, No. 12, 2014, pp. 1987-1992
Bioline Code: pr14273
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 13, No. 12, 2014, pp. 1987-1992
© Copyright 2014 - Tropical Journal of Pharmaceutical Research
Evaluation and Selection of Gel Base for the Formulation of Dexpanthenol Products|
Sipos, Emese; Szász, Noémi; Vancea, Szende & Ciurba, Adriana
Purpose: To formulate dexpanthenol gels with enhanced in vivo absorption properties via skin.
Methods: Carboxyvinyl derivatives (Carbopol 980 and Ultrez 10) and poloxamer (Lutrol F 127) were
used as the hydrogel base in the formulations. Changes in rheological properties (apparent viscosity
and penetration values) during the storage period were examined by Rheotest RN rotational viscometer
and PNR12 penetrometer. in vitro release study using Franz diffusion cell was employed to compare
the release characteristics of the formulated hydrogels with those of a reference cream.
Results: The flow curves of the gels with Carbopol 980 and Ultrez 10 showed pseudoplastic flow. Lutrol
F 127 gels presented thixotropic behaviour. The consistency of the studied gels was in the following
rank order: Lutrol F 127 > Ultrez 10 > Carbopol 980. in vitro results showed that dexpanthenol was
released in lower amounts from the reference cream than from the three test gels. No significant
differences were observed in the amount of active substance released from the gels due probably to the
fact that Carbopol 980 and Ultrez 10 are both carboxyvinyl polymers. The highest amount of
dexpanthenol was released from Lutrol F 127 gel.
Conclusion: The hydrogel made with Lutrol F 127 gel base possesses the best properties of all the
gels and is recommended for the formulation of a suitable dexpanthenol gel.
Hydrogel; Dexpanthenol; Carboxyvinyl polymers; Gels; Carbopol; Poloxamer; Rheology; Drug release; Penetrometer
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