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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 12, 2014, pp. 2027-2030
Bioline Code: pr14280
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 12, 2014, pp. 2027-2030

 en Evaluation of prophylactic Effect of Remifentanil on Succinylcholine-Induced Myalgia in Humans
Nasseri, Karim; Arasteh, Mehdi Taibi; Afkhamzadeh, Abdorrahim & Hakhamaneshi, Saeed

Abstract


Purpose: To assess the efficacy of remifentanil in preventing succinylcholine-induced myalgia in humans.
Methods: Sixty healthy adults scheduled for elective surgery under general anesthesia were enrolled in a double-blind study and randomly allocated to two groups of thirty patients. Patients in Group I (remifentanil group) were pretreated with remifentanil 1 μg/kg one minute prior to induction of anesthesia, while patients in Group II (saline group) received an equivalent volume of saline. Anesthesia was induced in both groups with fentanyl 1 μg/kg, propofol 2.0 mg/kg and succinylcholine 1.5 mg/kg. Postoperative myalgia was assessed 12, 24, and 48 h after induction and graded as nil, mild, moderate, or severe.
Results: Fifty nine patients completed the study. The demographic data for both groups were comparable (p > 0.05). Postoperative myalgia at 12, 24, and 48 h after induction were 34.5, 34.5 and 14.1 % in group I, and 60, 53.4 and 30 % in group II, respectively (p > 0.05).
Conclusion: Prophylactic use of remifentanil 1 μg/kg intravenously is ineffective in the prevention of postoperative myalgia

Keywords
Remifentanil; Succinylcholine; Myalgia; Propofol; Prophylaxis

 
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