To evaluate the antiglycation and hypolipidemic potential of polyphenols from Zingiber officinale
in streptozotocin-induced diabetic rats.
Diabetes was induced in male Wistar rats by single intraperitoneal injection of 50 mg/kg body
weight (bw) of streptozotocin. This was followed by oral administration of 500 mg/kg each of free and
bound polyphenol extracts of Z. officinale
to the rats daily for 42 days. Distilled water and glibenclamide
(5 mg/kg) were used as normal and positive controls, respectively.
Significant increases (p < 0.05) in blood glucose level (369.26 mg/dL), serum advanced
glycation end-products (AGEs) (6.80 ìg/mL), lipid profile and atherogenic indices, with decrease in high
density lipoprotein cholesterol (HDL-C) (15.55 mg/dL) were observed in diabetic rats compared to
control. Free polyphenol extracts of Z. officinale
significantly reduced (p < 0.05) blood glucose (147.96
mg/dL), serum AGEs (1.98 ìg/mL), lipid profile and atherogenic indices while it significantly increased
HDL-C (23.28 mg/dL). However, bound polyphenol extract did not cause any significant change in the
lipid profile of the diabetic rats except for LDL-C.
This study indicates that free and bound polyphenols from Z. officinale
diabetes as well as its complications, and its effect is comparable to that of the standard drug,