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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 1, 2015, pp. 179-185
Bioline Code: pr15025
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 1, 2015, pp. 179-185

 en Profiles of Diabetic Ketoacidosis in Multiethnic Diabetic Population of Malaysia
Usman, Atif; Sulaiman, Syed Azhar Syed; Khan, Amer Hayat & Adnan, Azreen Syazril

Abstract

Purpose: To outline first-time patient profiles of diabetic ketoacidosis (DKA) in the absence of reported incidence and mortality rates of DKA in Malaysian diabetic population.
Methods: A retrospective cross-sectional study was designed and all medical records of patients with a discharge note of DKA were reviewed. Admissions from January 2009 to December 2011 were included. Data were analyzed in terms of s°Cio-demographic variables in order to provide incidence and mortality rates. Medical history, as well as physical and bi°Chemical characteristics were analyzed to report epidemiology of DKA patients.
Results: Out of a total of 207 admissions for DKA, 132 were selected for the present study. Female (62.9 %), Malay ethnic (47.0 %) and the elderly (45.1 years and above) contributed most to DKA episodes. Type 2 diabetes mellitus (51.1 %) patients were prone to develop DKA. Most patients experienced mild to moderate episode of DKA by the time they sought medical attention. Although, there was no significant relationship between chronic co-morbidity and °Ccurrence of DKA, hypertension (54.5 %), dyslipidemia (43.0 %) and cardiac disorders (35.6 %) were, however, the most frequently observed co-morbidities. Non-adherence (43.2 %), sepsis (31.9 %) and respiratory tract infection (12.2 %) were the most encountered precipitating factors for DKA episode. Mortality rate was as high as 17.6 %.
Conclusion: With a higher incidence and mortality rate of DKA in Malaysia, the patterns observed in this study seem to be different from those of developed nations. Further extended studies need to be undertaken to elaborate regional and national patterns of DKA.

Keywords
Incidence; Mortality; Diabetic ketoacidosis; Diabetes; Hypertension; Cardiac disorders; Dyslipidemia; Comorbidity

 
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