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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 2, 2015, pp. 257-262
Bioline Code: pr15035
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 2, 2015, pp. 257-262

 en Effect of Phellodendron check for this species in other resources chinense Extract on Carrageenan- Induced Chronic Prostatitis in Rats
Lu, Can-Feng; Meng, Xiang-Hu; Li, Hui-Bing; Wu, Hao & Dou, Zhong-Ling

Abstract

Purpose: To investigate the effect of Phellodendron check for this species in other resources chinense Schneid (PCS) extracts on carrageenaninduced chronic prostatitis in rats.
Methods: Experimental chronic non-bacterial prostatitis (CNP) was induced in rats by injecting carrageenan into prostatitis. Rats in treated groups were administered either PCS extract or positive control (cernilton) for 3 weeks while those in the control group received saline instead. After treatment, prostate index (PI) and prostate-specific antigen (PSA) of all rats were examined by ELISA. The degree of chronic inflammatory cell infiltrates, acinar changes and interstitial fibrosis were evaluated by histopathological examination. In addition, relative inflammatory factors, viz, tumor necrosis factor-α (TNF-α), interleukin1β (IL-1β), cyclooxygenase-2 (COX-2), prostaglandin E2 (PEG2), transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) of prostate tissues of all the rats were measured by ELISA.
Results: High-dose PCS (400 mg/kg) significantly decreased PI (1.0 ± 0.1 mg/ml) relative to reference group (2.1 ± 0.2, p < 0.01) while high-dose PCS (400 mg/kg) significantly decreased PSA level (154.2 ± 14.3 pg/ml) relative to the reference group (312.5 ± 20.5 pg/ml, p < 0.01). Morphometric analysis demonstrated the presence of chronic inflammatory cell infiltrates, and interstitial fibrosis decreased significantly compared to the reference group. Compared with reference group (165.4 ± 14.2 pg/ml), TNF-α level in the prostate tissues of high-dose PCS group rats decreased (116.5 ± 9.3) significantly (p < 0.01). Similarly, compared with reference group (176.1 ± 12.1 pg/ml), IL-1β level of prostate tissues of high-dose PCS group rats decreased (97.6 ± 11.3) significantly (p < 0.01).
Conclusion: PCS extract has significant therapeutic effect on carrageenan-induced chronic prostatitis in rats.

Keywords
Phellodendron chinense; Chronic prostatitis; Chronic inflammation

 
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