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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 2, 2015, pp. 263-269
Bioline Code: pr15036
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 2, 2015, pp. 263-269

 en Anti-Hyperprolactinemic Effect of Formula Malt Decoction, a Chinese Herbal Cocktail
Li, Ming-xia; Liu, Hong; Li, Yan; Wang, Fei; Zhang, Pei-rong & Zang, Ping

Abstract

Purpose: To investigate the anti-hyperprolactinemic activity of Formula Malt Decoction (FMD), a Chinese herbal mixture.
Methods: The effect of FMD on serum prolactin (PRL), estradiol (E2), progesterone (PGN), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were investigated in hyperprolactinemic (hyperPRL) rats. The effect of FMD on PRL secretion, dopamine D2 receptor and dopamine transporters (DAT) were studied in MMQ cells derived from rat pituitary adenoma cells, GH3 cells derived from rat pituitary lactotropic tumoral cells and PC12 cells from rat pheochromocytoma, respectively.
Results: Compared with the model group, a high dose of FMD (11.6 g/kg body weight) and medium dose of FMD (5.8 g/kg body weight) reduced PRL level of hyperPRL rats effectively. In MMQ cells, treatment with 5 mg/ml FMD (p < 0.01) or 10 mg/mL FMD (p < 0.01) significantly suppressed PRL secretion and synthesis at 24 h compared with controls (p < 0.01). Consistent with D2- action, FMD did not affect PRL in rat pituitary lactotropic tumor-derived GH3 cells that lack the D2 receptor expression compared with controls, but 8 mg/mL FMD significantly increased the expression of D2 receptors (p < 0.01) and DAT (p < 0.01) in PC12 cells.
Conclusion: FMD shows anti-hyperprolactinemia activity via dopamine D2 receptor.

Keywords
Formula Malt Decoction; Hyperprolactinemia; Dopamine D2 Receptor; Prolactin; Estradiol; Progesterone follicle stimulating hormone; Luteinizing hormone

 
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