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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 2, 2015, pp. 337-349
Bioline Code: pr15046
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 2, 2015, pp. 337-349

 en Coordination Compounds of M(II) Biometal Ions with Acid - Type Anti - inflammatory Drugs as Ligands – A Review
Krstić, Nenad S.; Nikolić, Ružica S.; Stanković, Maja N.; Nikolić, Nada G. & Đorđević, Dragan M.

Abstract

The cations of biometals in biological systems easily interact with various moieties of organic and inorganic biomolecules, either as natural constituents or after introduction into the body via O - , N - and S - donor atoms. Study of the interaction between M(II) biometal – O - donor ligand (drug) is of interest for various reasons: more evenly dosing of medicine and biodistribution of medicine; monitoring of its pharmacokinetics including excretion; reduction of unwanted effects of the medicine; greater antimicrobial activity; synergistic effect of the metal and medicine; and improved anti - ulcer ous, anti - tumor and anti - bacterial activity. This paper offers an overview of the literature of published research on coordination between biometals and anti - inflammatory drugs of the acid type. The metals that the subject of focus in this review are d - met als with M(II) ions, namely, copper (Cu), zinc (Zn), cobalt (Co) and manganese (Mn).Those containing molecules with carboxyl functional groups can build complexes with coordinated number of metals of 4 and 6, of various stoichiometric structures, simple or complex, and also behave as monodentate, bidentate or bridge ligands in polynuclear complexes.

Keywords
Biometals M(II); Anti - inflammatory medicin; Coordination; O - Donor ligands; Copper; Cobalt; Manganese; Zinc

 
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