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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 14, No. 3, 2015, pp. 371-377
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Bioline Code: pr15049
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 14, No. 3, 2015, pp. 371-377
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Embedment of Chlorpheniramine Maleate in Directly Compressed Matrix Tablets of Compritol and Kollidone SR
Fouad, Ehab A.; Ibrahim, Mohamed A. & El-Badry, Mahmoud
Abstract
Purpose: To study the effect of compritol ATO888 and kollidon SR blend on the release of
chlorpheniramine maleate (CPM) from its matrix tablets prepared by direct compression.
Methods: Different ratios of compritol and kollidon SR (containing 50 % matrix component) in 1:1, 1:2,
1:3 and 3:1 ratios were formulated using direct compression. The formulations were organoleptically
tested and investigated for CPM release.
Results: The release kinetics showed Fickian diffusion mode for kollidone and anomalous release
mechanism for compritol matrices. Combining compritol as a lipophilic material and kollidone produced
a matrix with controlled drug release. Retardation of drug release rate depended on the ratio of
compritol to kollidon. The lower the compritol component, the slower the drug release rate. CPM in
matrix tablets containing compritol:kollidone SR in a ratio of 1: 3 achieved optimized sustained release,
where 44 % of the drug was released within 8 h (versus 94.5 % for compritol and 54.2 % for kollidon
matrix systems). The kinetics of drug release followed Fickian diffusion at low compritol concentration in
the blend, reflecting the importance of pore formation. However, when compritol proportion was
increased, drug release followed non-Fickian anomalous kinetics due to the water-repelling effect of
compritol.
Conclusion: Compritol content of CPM matrix tablets can be used to modulate drug release rate as
well as release kinetics.
Keywords
Chlorpheniramine maleate; Matrix tablets; Compritol; Kollidon; Drug release; Release kinetics
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