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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 3, 2015, pp. 479-485
Bioline Code: pr15063
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 3, 2015, pp. 479-485

 en Antifatigue Effect of Millettiae speciosae check for this species in other resources Champ (Leguminosae) Extract in Mice
Zhao, Xiao Ning; Wang, Xiu Fen; Liao, Jin Bin; Guo, Hui Zhen; Yu, Xiao Dan; Liang, Jia Li; Zhang, Xie; Su, Zi Ren; Zhang, Xiao Jun & Zeng, Hui Fang


Purpose: To evaluate whether Millettiae speciosae check for this species in other resources Champ. (Leguminosae) can enhance exercise performance as well as ascertain if it a potential functional food material.
Methods: The extract of Millettia speciosa Champ. (MSE) was orally administered to mice in 500, 1000, 2000 mg/kg doses to investigate its anti-fatigue effect in both forced swimming and climbing tests. Glycogen, triglyceride (TG), blood urea nitrogen (BUN) and creatine phosphokinase (CK) levels in plasma which can indicate alterations in energy utilization during exercise performance, were determined to analyze the operating exercise mechanisms.
Results: The results showed that swimming time to exhaustion was longer in all treated groups (41.06 ± 1.92, 47.84 ± 1.60, 54.00 ± 2.45 min for 500, 10000 and 2000 mg/kg doses, respectively) than for control (19.45 ± 0.62 min, p < 0.05). The middle and high doses of MSE-treated groups significantly prolonged the climbing time compared with control (p < 0.05). Furthermore, MSE reduced the content of TG significantly by increasing fat utilization, delayed the accumulation of BUN and decreased the level of CK (p < 0.05). In addition, administration of MSE significantly protected the depletion of muscle glycogen when compared with control (p < 0.05).
Conclusion: The results show for the first time that Millettia speciosa Champ. (Leguminosae) has significant anti-fatigue activity, and also suggest that it is a potential functional food material. Keywords: Radix millettiae speciosae, Anti-fatigue activity, Exercise performance, Serum urea nitrogen, Gastrocnemius muscle glycogen, Triglyceride, Functional food

Radix millettiae speciosae; Anti-fatigue activity; Exercise performance; Serum urea nitrogen; Gastrocnemius muscle glycogen; Triglyceride; Functional food

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